Regina's tribal group is Wunumbul which is one of the three tribes that are custodians of the Wandjinas and Gyorn Gyorn people, within the Kimberley region. Regina comes from a family of well-known painters from her region. Rosie and Louis Karadada, her parents (both deceased) taught her how to paint and taught her the stories and significance of the artwork. Lily Karadada (or mum Lily as Regina calls her, the Aboriginal way), is the sister-in-law of Regina's dad, Louis (Lily is married to Jack Karadada, Louis's eldest brother.) Her themes are the Wandjinas and Gyorn Gyorn figures, the spirit creators of her families region.